Clinical Studies - Scientific Proof ( HgH Amino Acids )
Excerpts from Research Studies on the Hgh Amino Acids
Prove that the Ingredients Used in Advanced GHR Platinum
Hgh Releasers ( Hgh Enhancers / Hgh Boosters ) Really Work
Dr. LE Dorman, MD - Growth Hormone / Amino Acid Blend
Author of "The Methusaleh Factor"
As we age, our body stops producing an adequate supply of HGH amino acids. Out of the 191 amino acids in the Growth Hormone chain, GHR PLATINUM replenishes the body with the needed blend of Stacked HGH amino acids in the Right Ratio and Molecular Weight that helps Stimulate and Restore the Release of your body’s own natural Growth Hormone. Many substances stimulate the release of Growth Hormone from the Pituitary Gland. Amino acids ( from HGH chain ), drugs and exercise are among the provocateurs." ( Page 35 )
Amino Acid: L-ARGININE
The Amino Acid - ARGININE works in two significant ways in the human body:
First, it is a precursor used to make other substances. For example, it works by converting into the special compound Nitric Oxide. This substance plays a vital role in various metabolic activities. These include the regulation of the flow of blood, various cellular processes to create energy, and sending communications between the cells.
Nitric Oxide also functions as a Vasodilator by dilating and relaxing blood vessels. This improves the circulation of the blood throughout the entire body. The result of this helps to lower high blood pressure. This also enables more nutrients from food and supplements, as well as oxygen in the blood - to be delivered to all the organs, muscles, tissues and cells of the body. In these ways, ARGININE helps promote a healthy functioning of the Heart. Consequently, this amino acid can useful in providing relief for conditions like Hypertension, diseases of the Circulatory System, Angina and Erectile Dysfunction ( ED ).
At the same time, Nitric Oxide also aids in the removal of waste products ( Lactate and Ammonia ) from both the Liver and the muscles, that are the by-products of metabolism. By removing those toxic substances from the body, it helps the muscles, and the whole body, to more rapidly recover from physical exercise and strenuous workouts.
Second, ARGININE is also use to help the body to form Proteins. It also promote a healthy functioning of the Immune System. It is also used in the Digestive Process to digest glucose ( sugars ). In this capacity, it might help improve Insulin Sensitivity. There are some research studies that suggest that in this way it could helpful to provide relief for people who suffer from Diabetes Type 2.
One of the symptoms of the Aging Process is that as we grow older, our bodies often do not produce enough Arginine. Or else we simply do not produce it very effectively. Thus, it often becomes necessary for older people to increase their daily intake of Arginine by using supplements.
During the last approximately thirty years, there have been many clinical research studies and trials by scientists, to learn more about the effects of amino acids on levels of Human Growth Hormone ( HGH ). In particular, these include ARGININE and LYSINE. The studies repeatedly prove that boosting the circulating amounts of these two amino acids increases the production of Growth Hormone ( GH ) and release by the Pituitary Gland. These amino acids, along with certain other specifc ones, are included in the Doctor-Approved formulas of the GHR PLATINUM Anti-Aging HgH Releaser supplements. Below we have provided some of these studies, which prove that these amino acids really work as Growth Hormone Releasers ( GHR ).
Growth Hormone Responses to Varying Doses of Oral Arginine
https://pubmed.ncbi.nlm.nih.gov/15809017/
"5 and 9 grams of oral ARGININE caused a significant ( Growth Hormone ) GH response"
Growth Hormone, Arginine and Exercise
https://pubmed.ncbi.nlm.nih.gov/18090659/
"Most studies using oral ARGININE have shown that ARGININE alone increases the resting Growth Hormone levels at least 100%"
Increased Human Growth Hormone Following Oral Consumption
of an Amino Acid Supplement: Results of a Randomized,
Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects
https://pmc.ncbi.nlm.nih.gov/articles/PMC6732240/
"It is well established that intravenous (IV) administration of some amino acids results in significantly increased HgH secretion. Such studies prompted testing of oral amino acids supplements ( primarily ARGININE, LYSINE & Orthinine ) to stimulate HgH secretion." ( Both Arginine and Lysine are included in the GHR Platinum HgH Amino Acids Blend )
A Study of Growth Hormone Release in Man After Oral Administration of Amino Acids
https://pubmed.ncbi.nlm.nih.gov/6790230/
"A study was carried out in [ fifteen ] 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids ( 1,200 mg L-LYSINE plus 1,200 mg L-ARGININE ) provoked a release of Pituitary Somatotropin { related to GH } and Insulin."
"This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity ( as demonstrated by a radioreceptor assay and somatomedin induction ). The effect appeared to be specific to the combination of the two amino acids."
Acute Effect of Amino Acid Ingestion and Resistance Exercise
on Plasma Growth Hormone Concentration in Young Men
https://pubmed.ncbi.nlm.nih.gov/9063764/
Sixteen men completed four trials at random as follows:
Trial A - Performance of a single bout of resistance exercise preceded by placebo ingestion ( Vitamin C );
Trial B - Ingestion of 1,500 mg L-ARGININE and 1,500 mg L-LYSINE, immediately followed by exercise as in Trial A;
Trial C - Ingestion of amino acids as in Trial B and no exercise;
Trial D - Placebo ingestion and no exercise.
Growth Hormone ( GH ) concentrations were higher at 30, 60, and 90 min during the ( two ) exercise trials ( A and B ) compared with the resting trials ( C and D ). No differences were noted in Growth Hormone [ GH ] between the exercise trials.
It was concluded that ingestion of 1,500 mg ARGININE and 1,500 mg LYSINE immediately before resistance exercise does not alter exercise-induced changes in Growth Hormone [ GH ] in young men.
However, when the same amino acid mixture ( 1,500 mg ARGININE and 1,500 mg LYSINE ) is ingested under basal conditions, the acute secretion (release) of [ Growth Hormone ] GH is increased.
Amino Acid: L-LYSINE
The Amino Acid - LYSINE is one of the eight ( 8 ) Essential Amino Acids. This means that our bodies can NOT make them. We need to get them from proteins in foods which we eat. Otherwise, we must obtain them from supplements that contain them in forms which our bodies can readily digest and use.
LYSINE is one of the vital amino acids, because it is necessary to create the other proteins in the body. It is also critical to make muscle tissues, and to synthesize hormones, enzymes and anti-bodies. It also plays a pivotal part in absorbing the Mineral Calcium, while at the same time, it helps to diminish the loss of calcium in urine. It also reduces Cholesterol levels.
Like the amino acid GLUTAMINE, it helps the body to heal and repair tissues and cells and recover from injuries and wounds. It acts as a Binding Agent, to help increase the number of new cells in an injury or wound that is healing. Together with the amino acid GLYCINE, it is required to form Collagen, that is used to form skin, nails, hair, and various connecting tissues in the body.
It is a precursor to L-Carnitine, which is a derivative of amino acids, and found in most cells of the body. This substance is important to enable the Nervous System to function properly. Lysine is likewise a precursor for the compound L-Carathine, that is similarly required to maintain a healthy Nervous System.
Carnitine carries LONG-CHAIN FATTY ACIDS across the Mitochondria of cells and then consumes them to create energy for metabolism. Afterwards it then removes the toxins, created from the metabolic processes, out of the cells. Lysine is also critical for normal physical growth. So, a lack in the amount of Lysine can lead to all kinds of health issues and problems, such as dizziness, nausea, fatigue and slowed physical growth.
Three ( 3 ) of the studies above included both ARGININE and LYSINE, which prove that LYSINE is also a Growth Hormone Releaser ( GHR ).
Amino Acid: L-GLUTAMINE
The Amino Acid - GLUTAMINE is a vital amino acid that supports healthy Brain Function. It is needed for the creation of both RNA and DNA. It affects the secretion of Growth Hormone ( GH ) which then begins a process in the body which is known as "NeuroGenesis". This is the way in which new neuron cells in the brain are made. It also supports the on-going maintenance and functioning of existing brain cells.
In a similar way, the levels of Growth Hormone ( GH ) also affect the levels of NeuroTransmitters in the brain. These are critical for many functions, processes and activities in the body. In particular, GLUTAMINE is a powerful amino acid that is also a precursor for the making of the NeuroTransmitters GABA and Glutamate. These brain NeuroTransmitters also help to regulate and support various Cognitive Functions, including mood, concentration and memory. GABA is also included in the formulations of the GHR PLATINUM products as one of the HgH Enhancers Complex.
Research studies demonstrate that small amounts of supplementation with GLUTAMINE can stimulate an observable increase in Growth Hormone ( GH ) levels in the body. For example, some clinical studies have shown that only 2 mg of this powerful amino acid could temporarily elevate the levels of Human Growth Hormone ( HGH ) by as much as 78%.
GLUTAMINE is also a precursor to create the amino acid ARGININE, that we explained earlier. We have seen from the information and studies given above, that it is clinically proven to stimulate the Pituitary Gland to increase its production and secretion of Growth Hormone ( GH ). Thus, when you increase your intake of Glutamine, by eating more proteins, or by takings supplements, you enable your body to raise the levels of ARGININE and the NeuroTransmitters GABA and Glutamate as well.
How does GLUTAMINE work to cause more Growth Hormone ( GH )? The NeuroTransmitter Glutamate plays a largo role in stimulating certain cells in the the Pituitary Gland called Somatotrophs. These are the special cells which signal the production and secretion ( release ) of Growth Hormone ( GH ).
GLUTAMINE happens to be the most abundant amino acid found in the blood and in fluids of the body. It has many important functions. It is used to create proteins, produce energy, and help with detoxification and removal of waste products ( ie: Ammonia ), from metabolic activity.
Additionally, this amino acid is needed for a healthy functioning of the Gastro-Intestinal Tract. It also provides energy for White Blood Cells and for growth and maintenance of certain cells in the Intestines. There, it helps to maintain the barrier that separates the inside of the Intestines and the rest of the body. In this capacity, it enables your body to maintain a healthy gut. This protects against getting what is called a "Leaky Gut". Thus, in this function, it also works to promote a healthy functioning of the Immune System.
When a person is going through times of a lot of stress, or has a sickness, illness or severe injury, their bodies can become depleted of Glutamine. In such times, the body typically needs more Glutamine for the healing and recovery process. When there are injuries and wounds, the body requires it to repair damaged tissues and cells. At such times, if more Glutamine is needed than the body can make on its own, it must obtain it from elsewhere. So what happens is that the body might then break down proteins stored in muscles tissues, to release it from there.
When a person is experiencing stress that are very high, the body produces higher levels of CORTISOL. This is known as the "Stress Hormone". So is there a connection between Stress and HgH levels in the body. Scientists have learned that CORTISOL can block the production of Growth Hormone (GH). Thus, when you reduce the amount of stress you have, you can also reduce the amount of CORTISOL that blocks the production and release of the very Growth Hormone which you need and want to increase.
There is also a connection between FAT BURNING in the body and Growth Hormone ( GH ). Growth Hormone actually helps in the process to breakdown fats, through what is called "LIPOLYSIS". In this way, FATS other LIPIDS are converted to FATTY ACIDS. There is also a similar link between the metabolism of Carbohydrates and Growth Hormone. This then has a direct affect on blood sugar levels.
Thus GLUTAMINE is involved in significant ways in the entire Digestive Function and also the conversion of Starches, Sugars and Fats into workable energy for many activities of body metabolism. Therefore this vital amino acid Glutamine also has a huge affect on weight loss. So it is important to maintain sufficient levels of both GLUTAMINE ( and ARGININE ). And since both of these amino acids participate in stimulating the production and release of your Growth Hormone, they both provide important health benefits for us - physically, mentally and emotionally.
Research studies prove that high levels of BODY FAT, particularly BELLY FAT, block and reduce the production and secretion of Growth Hormone ( GH ). Therefore, the amount of FAT ( Adipost TIssue ) which men and women carry in their bodies, especially in their BELLIES, greatly affects the ability of their bodies, in a negative way, to produce of Growth Hormone. Consequently, if you can lose excess weight, especially BELLY FAT, then you can help your body to naturally increase your HGH output. And GHR PLATINUM products can help you to lose weight and increase your HGH levels as well.
Increased Plasma Bicarbonate & Growth Hormone After Oral Glutamine Load
https://pubmed.ncbi.nlm.nih.gov/7733028/
"An oral GLUTAMINE load was administered to nine healthy subjects to determine the effect on Plasma Glutamine, bicarbonate, and circulating Growth Hormone concentrations. These findings demonstrate that a surprisingly small oral GLUTAMINE load is capable of elevating alkaline reserves as well as plasma Growth Hormone ( GH )."
AMINO ACID: GLYCINE
L-GLYCINE is the second most abundant amino acid in the body, that is used form various proteins. It is the most important of the amino acids required to create Collagen. Collagen is necessary for the formation of nails, skin, hair and various connective tissues in the body. This amino acid also aids in building muscles ( and energy in the muscles ), bones, supporting a proper functioning of the Brain, including healthy Sleep Patterns.
Glycine is part of the building blocks of making the Tri-Peptide Glutathione ( an AntiOxidant that is found in the cells ). This substance is derived from the three ( 3 ) Amino Acids: Glutamic Acid, Cysteine, and GLYCINE.
Another of the symptoms of the Aging Process, is that as we grow older, ( as with the Amino Acid ARGININE ), our bodies often have a reduced ability to make this Anti-Oxidant Glutathione. So we most likely need to take a supplement to get enough of it.
The AntiOxidant Glutathione helps the body prevent damage and disease to organs ( especially the Liver ) , tissues and cells, that Free Radicals can cause. When parts of the Liver that are damaged form Fibrous Tissues, they can become scarred. Or the Liver itself can become diseased through the accumulation of excessive FAT, which is a condition called FATTY LIVER. Consumption of alcohol and various immune attacks can also cause the Liver to become damaged.
Glycine also works as a NeuroTransmitter in the brain. In this capacity, it works to support the processing of motor and sensory information, which enables movement, vision and hearing. It also works by helping to calm the Central Nervous System.
And as with the amino acid Glutamine, so also with the Glycine. During periods of excessive of stress, sickness or injury, our bodies need more of it , to help repair tissues and cells and assist in the healing of wounds. But in those times, the ability of our bodies to make this critical amino acid can often become severely affected.
And lastly, this amino acid participates in the Digestive Process. It helps in the process of digesting FATS by regulating the release of Bile Acids from the Gall-Bladder into the Small Intestine. Meanwhile, it also functions as what is called a "Glucogenic Amino Acid". This means that the Liver can convert it into Glucose ( Sugar ).
There have been numerous research studies which show and prove the link between levels of Glycine and levels of Human Growth Hormone ( HgH ). Here are just a few of them:
Stimulatory Effect of Glycine on Human Growth Hormone Secretion
https://pubmed.ncbi.nlm.nih.gov/622050/
"GLYCINE was administered orally to 19 non-Obese normal subjects and 12 subjects with partial gastrectomy. In the normal subjects, a clear and significant increase of serum Human Growth Hormone ( hGH ) level was observed."
"The facts demonstrated that Glycine is one of the stimulatory agents inducing the Pituitary Gland to secrete HgH."
Glycine Stimulated Growth Hormone Release in Man
https://pubmed.ncbi.nlm.nih.gov/7376793/
"The influence of GLYCINE, the simplest amino acid, on Pituitary Function has been investigated in the present study. Different doses ( 4, 8, or 12 grams ) of Glycine were intravenously infused over 15 or 30 min in normal subjects.
The dose of 4 or 8 grams [ of ] Glycine induced a significant increase in serum [ Growth Hormone ] GH; however, a more pronounced and significant increase in serum [ Growth Hormone ] GH levels was observed after infusion at a dose of 12 grams [ of ] GLYCINE. The present data suggests that GLYCINE might play an important role in the control of Hypothalamic - Pituitary Function."
Reduced Plasma Glycine Concentration in Healthy and Chronically Diseased
Older Adults: a Marker of Visceral Adiposity { Fat }?
https://pubmed.ncbi.nlm.nih.gov/38616018/
"Previous studies have shown that a reduced plasma concentration of the amino acid [ GLYCINE ] GLY is associated with intra-abdominal obesity, but the mechanism remains unclear. This study aimed to investigate whether lower plasma [ GLYCINE ] GLY concentrations in older adults are independently associated with ( Visceral ) Adiposity { Condition of being FAT }, age, sex, presence of chronic disease, & glucose intolerance, and whether they are caused by a reduced [ GLYCINE ] GLY Whole-Body Production ( WBP ) and/or increased GLY disposal capacity."
"We studied 102 older adults ( 47 males / 55 females ). We assessed body composition and { Visceral Adiposity Tissue } VAT. The strong association between lower plasma [ GLYCINE ] GLY and increased { Visceral Adiposity Tissue } VAT mass in older adults was independent of age, sex, body weight, lean mass or body mass index, and the presence of COPD."
"Reduced plasma [ GLYCINE ] GLY in older adults can be considered a marker of Visceral Adiposity, independent of sex, age, body composition, presence of chronic disease, and whole-body GLY production or clearance."
The Effect of Glycine Administration on the Characteristics
of Physiological Systems in Human Adults: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/37851316/
"Functional decline of Physiological Systems during Aging leads to Age-Related Diseases. Dietary Glycine increases healthy lifespan in model organisms. and might decrease inflammation in humans, suggesting its gero-protective potential. This review summarizes the evidence of Glycine administration on the characteristics of eleven Physiological systems in adult humans. The Nervous System demonstrated the most positive effects, including improved psychiatric ( mental ) symptoms from longer-term Glycine administration; longer-term Glycine administration improved sleep in healthy populations."
AMINO ACID: TYROSINE
The Amino Acid - TYROSINE is derived from PHENYLALANINE, one of the eight ( 8 ) Essential Amino Acids. So, if we lack enough Phenylalanine, we will also be deficient in Tyrosine as well. Thus, we need to eat enough proteins in our diets that contain it. Otherwise, we need to get more of it by taking supplements.
Tyrosine is used to make various proteins. For example, it is involved in the making of the various Thyroid Hormones
( Thyroxin ) which helps to manage Metabolism ), the Adreno-Cortical Hormones, Melanin ( a color pigment found in the hair, skin and iris of the eyes ), Enzymes, and also various brain Neuro-Transmitters.
The NeuroTransmitters in our brains are involved with our Cognitive Abilities, including these: concentration, focus, memory, working memory, mood, Cognitive flexibility ( ability to switch tasks or change thoughts ) and following instructions.
This amino acid is also a precursor for the following NeuroTransmitters / Hormones - Dopamine, Epinephrine, Norepinephrine, Adrenaline and Noradrenaline. Each of these substances can affect the release / secretion of HgH in the Pituitary Gland.
Dopamine is crucial for our Mental Functioning and Mood. It regulates the reward and pleasure centers. This important compound is also critical for Memory and Motor ( Movement ) Skills.
Adrenaline and Noradrenaline are hormones that are used what is known as in the "Fight-or-Flight Response" in stressful circumstances. They enable us to stand and fight, or flee and run - from an actual attack or perceived harm. In these various ways, the amino acid Tyrosine helps us to balance the affects of both physical and mental stress. When we are under a burden of stress, we sometimes have difficulty thinking clearly and remembering things. Research studies have shown that Tyrosine supplementation can help support and improve Cognitive Abilities in such conditions. Various research studies that have been performed, have shown that Tyrosine helps to lower anxiety and stress levels, and aids us to be more mentally alert.
Similarly, Tyrosine plays a part in the synthesis of certain special substances in the brain called "Enkephalins". These provide pain-relieving effects to the body. They also transmit nerve impulses and signals, and prevent conditions such as depression.So they are vital to the healthy functioning of our brains.
Additionally, this amino acid also plays a role in the regulation of Blood Pressure. And like other amino acids, it is used to decrease BODY FAT. Earlier, we have explained that excess BODY FAT, especially BELLY FAT, inhibits and blocks the production of HGH. Lastly, this amino acid also works an AntiOxidant, helping to protect the body from damage that Free Radicals can cause to organs, tissues, muscles and cells.
There has been a lot research to learn how Tyrosine works with the Pituitary Gland to stimulate it to secrete Growth Hormone ( GH ). There may be an increase in the release of our GH at particular times, particularly in periods of stress.
One research study discovered that it has a major role in promoting increased levels of both HGH and IGF-1 ( Insulin Growth Factor - 1 ) especially in circumstances of high stress, or during intensive physical workouts. Scientists think that it works by activating the Enzyme - called Tyrosine Kinase, which then functions as a messenger, to tell the Pituitary Gland to start various metabolic processes that are linked to the production and release of Growth Hormone ( GH ).
Meanwhile, clinical studies have shown that TYROSINE becomes more effective at elevating Human Growth Hormone ( HgH ) levels, when it is combined with two other specific amino acids. And these are ARGININE and LYSINE. As presented above, there is already a lot of research that clearly demonstrates the ability of both ARGININE and LYSINE, to elevate HGH levels. So when TYROSINE is also added, there is a more significant increase in the production and release of Growth Hormone ( GH ).
Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task
https://pmc.ncbi.nlm.nih.gov/articles/PMC3863934/
"We tested the idea that the food supplement L-Tyrosine ( TYR ) repletes { provides / supplies } resources required for Cognitive-Control Operations. We investigated whether the “updating” ( and monitoring ) of Working Memory ( WM ) representations, a key Cognitive-Control Function, can be promoted by administering L-Tyrosine, the biochemical precursor of Dopamine ( DA )."
"Interestingly, executive control has been considered to emerge from the interplay between cognitive stability ( defined as the maintenance of task-relevant representations ) and flexibility ( defined as the ability to adapt, update, and shift between informational states ) – two major, but partially antagonistic functions of Cognitive Control, related correspondingly to the PreFrontal Cortex ( PFC ) and the Striatum, which both are modulated by Dopamine ( DA ) - the precursor of which is L-Tyrosine ( TYR )."
"The current study focused, for the first time, on the acute effect of L-Tyrosine supplementation on the updating (and monitoring) of Working Memory ( WM ) representations, a key Cognitive Control Function. We tested whether WM updating can be promoted by administering the food supplement Tyrosine ( TYR ). We investigated the link between L-Tyrosine supplementation and the monitoring of WM in healthy adults exposed to an oral dose of either Tyrosine ( TYR ) or a neutral placebo."
"The present study is the first to demonstrate that Tyrosine supplementation promotes Working Memory ( WM ) updating. As expected, the more challenging 2-back condition was more sensitive to the effect of Tyrosine, which reinforces our suspicion that only tasks with considerable Cognitive Demands benefit from Tyrosine. As we have argued in the introduction, this may be because more demanding Cognitive Control are more likely or more efficient to exhaust the available Cognitive Resources, which can then be repleted { provided / supplied } by Tyrosine."
Tyrosine Promotes Cognitive Flexibility: Evidence From Proactive vs. Reactive Control During Task Switching Performance
https://pubmed.ncbi.nlm.nih.gov/25598314/
"Tyrosine ( TYR ), an amino acid found in various foods, has been shown to increase Dopamine ( DA ) levels in the brain. Recent studies have provided evidence that Tyrosine ( TYR ) supplementation can improve facets of Cognitive Control in situations with high Cognitive demands."
"Here we investigated whether Tyrosine promotes cognitive flexibility, a cognitive-control function that is assumed to be modulated by Dopamine ( DA ). We tested the effect of TYR on proactive vs. reactive control during task switching performance, which provides a relatively well-established diagnostic of cognitive flexibility. In a Double-Blind, Randomized, Placebo-Controlled design, 22 healthy adults performed in a task-switching paradigm."
"Compared to a neutral placebo, Tyrosine ( TYR ) promoted Cognitive Flexibility ( ie: reduced switching costs ). This finding supports the idea that Tyrosine can facilitate Cognitive Flexibility by repleting { filling / supplying } Cognitive resources."
Behavioral and Cognitive Effects of Tyrosine Intake in Healthy Human Adults
https://pubmed.ncbi.nlm.nih.gov/25797188/
"The amino acid Tyrosine is the precursor to the catecholamine NeuroTransmitters Dopamine and Norepinephrine. Increasing Tyrosine uptake may positively influence catecholamine-related Psychological Functioning."
"We conducted a systematic review to examine the effects of Tyrosine on behavior and Cognition. Fifteen studies were reviewed. All studies except one involved Tyrosine loading during a single test session. In most behavioral studies, there were no significant effects of Tyrosine on exercise performance."
"In contrast, Cognition studies employing neuro-psychological measures found that Tyrosine loading acutely counteracts decrements ( gradual decreases ) in Working Memory and Information Processing that are induced by demanding situational conditions such as extreme weather or cognitive load."
"The buffering effects of Tyrosine on Cognition may be explained by Tyrosine's ability to neutralize depleted brain catecholamine levels. There is evidence that Tyrosine may benefit healthy individuals exposed to demanding situational conditions."
Increased Human Growth Hormone Following Oral Consumption of an
Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects
https://pmc.ncbi.nlm.nih.gov/articles/PMC6732240/
"Does an investigational amino acid supplement affect HgH release? This was a Randomized, Placebo-Controlled, Double-Blind, crossover study that included 16 ( 12 males, 4 females ; Age 32 ±14 years ) healthy participants. All participants received both placebo and the amino acid supplement after an overnight fast and completed all study visits. Treatment order was randomized and each treatment was separated by a 1-week washout period."
"The primary outcome were the percent change in HgH from baseline to 120 minutes and the area under the curve of hGH over baseline. At 120 minutes, HgH levels increased by 682% ( 8-fold ) from baseline and were significantly higher than placebo. In addition, a significantly higher mean AUC was observed for the amino acid supplement compared to placebo."
"These results show that a single dose of the oral amino acid supplement was sufficient to significantly increase hGH levels in healthy adult males and females."
Effect of Tyrosine Supplementation on Clinical and Healthy Populations
Under Stress or Cognitive Demands - A Review
https://pubmed.ncbi.nlm.nih.gov/26424423/
"Consuming the amino acid Tyrosine ( TYR ), the precursor of Dopamine ( DA ) and Norepinephrine ( NE ), may counteract decrements ( gradual decreases ) in neurotransmitter function and cognitive performance. However, reports on the effectiveness of Tyrosine ( TYR ) supplementation vary considerably, with some studies finding beneficial effects, whereas others do not. Here we review the available cognitive/behavioral studies on Tyrosine ( TYR ), to elucidate whether and when TYR supplementation can be beneficial for performance."
"In contrast, Tyrosine ( TYR ) does seem to effectively enhance Cognitive Performance, particularly in short-term stressful and / or Cognitively demanding situations. We conclude that Tyrosine ( TYR ) is an effective enhancer of Cognition, but only when NeuroTransmitter function is intact and Dopamine ( DA ) and / or Norepinephrine ( NE ) is temporarily depleted."